AbbVie is seeking a driven and innovative Scientist II, In Vitro Pharmacology, to join the mRNA-tLNP group. The Scientist II, In Vitro Pharmacology, will develop and perform cell-based assays to generate data that advance mRNA-tLNP pipeline programs from early discovery through IND-enabling studies, with an emphasis on applications in oncology and autoimmune diseases. Responsibilities Lead the design, optimization, and execution of in vitro assays to evaluate mRNA-tLNP-mediated T-cell reprogramming, including assessment of cytotoxicity, T-cell effector function, and immune cell phenotyping. Develop and deliver high-quality in vitro data packages to drive progression of the in vivo mRNA-tLNP pipeline programs, proactively leveraging cross-functional expertise by collaborating closely with research, bioinformatics, translational, and project management teams. Actively pursue mastery of innovative experimental techniques and emerging scientific tools to enhance scientific rigor, while serving as a subject matter resource and mentor to teammates, fostering a culture of continuous learning and knowledge sharing within the group. Exhibit and maintain a high level of technical proficiency and scientific acumen within the field of in vitro pharmacology, demonstrating expertise in experimental design, data interpretation, and troubleshooting. Independently establish, monitor, and deliver on project milestones and experimental timelines, ensuring alignment with program goals and organizational priorities, while maintaining flexibility to adapt to evolving scientific needs. Organize, analyze, and synthesize complex scientific data, and effectively communicate experimental strategies, results, and interpretations to internal and external stakeholders through clear and impactful presentations and scientific reports. Make substantive contributions to scientific publications, patent applications, and conference presentations by providing conceptual input, technical writing, data analysis, and critical review, in alignment with AbbVie's standards of scientific excellence and innovation.
BS or equivalent education with typically 7 or more years of experience or MS or equivalent education with typically 5 or more years of experience, in immunology, cell and molecular biology or related field. Demonstrated ability to independently design, perform, and interpret key experiments to address scientific questions. Proven capacity to quickly learn and apply new laboratory techniques. Able to manage multiple tasks efficiently while meeting deadlines. Strong skills in scientific writing and verbal communication. Previous experience in chimeric antigen receptor (CAR) production and evaluation is desirable. Deep expertise in primary human T-cell biology, including isolation, activation, and specialized expansion protocols, cytotoxicity, proliferation and cytokine profiling. Mastery of high-parameter flow cytometry (panel design and data deconvolution) and molecular techniques such as ddPCR or RT-qPCR. Experience with scientific data analysis software including CellEngine and Tableau is desirable.
Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future. We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees. This job is eligible to participate in our short-term incentive programs. Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: https://www.abbvie.com/join-us/reasonable-accommodations.html